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Publication List (English)
2020
56. Kagotani K, Nakayama H, Zang L, Fujimoto Y, Hayashi A, Sono R, Nishimura N, Shimada Y*. Lecithin-based dermal drug delivery for anti-pigmentation maize ceramide. Molecules. 2020;25;1595. - Equally contributed first and corresponding author.

55. Chensom S, Shimada Y, Nakayama H, Yoshida K, Kondo T, Katsuzaki H, Hasegawa S and Mishima TDetermination of anthocyanins and antioxidants in ‘Titanbicus’ edible flowers in vitro and in vivo. Plant Food Hum Nutr. 2020;in press.

54. Shimada Y*, Hazekawa MDeveloping a model for a siRNA delivery system by cancer implantation into zebrafish circulationMethods Mol Biol. 2020;in press. - First and corresponding author.

53. Yamada Y, Chensom S, Yonemoto H, Nakayama H, Zang L, Nishimura N, Mishima T, Shimada Y*. Water extract of Yamato-Tachibana (Citrus tachibana) induces food intake in adult and larval zebrafish. J Med Food. 2020;23:65-71. - Corresponding author.

2019
52. Sawaki R, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-AutoML: An easy machine learning-based method to detect anomalies in fluorescent-labelled zebrafishInventions. 2019;4:72. - Corresponding author.


50. Zang L, Shimada Y, Nakayama H, Kim Y, Chu D, Juneja LR, Kuroyanagi J, Nishimura N. RNA-seq based transcriptome analysis of the anti-obesity effect of green tea extract using zebrafish obesity models. Molecules. 2019;24:3256.

49. Monma Y, Shimada Y, Nakayama H, Zang L, Nishimura N, Tanaka T. Aging-associated microstructural deterioration of vertebra in zebrafishBone Rep. 2019;11:100215.- Equally contributed first author.

48. Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N. Therapeutic silencing of centromere protein X ameliorates hyperglycemia in zebrafish and mouse models of type 2 diabetes mellitus. Front Genet. 2019;10:693.

47. Kawada T, Kuroyanagi J, Okazaki F, Taniguchi T, Suda N, Abiko S, Kaneco S, Nishimura N, Shimada Y*. An integrative evaluation method for the biological safety of down and feather materials. Int J Mol Sci. 2019;20:1434. - Corresponding author.

46. Vranic S, Shimada Y*, Ichihara S*, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G. Toxicological evaluation of SiO2 nanoparticles by zebrafish embryo toxicity test. Int J Mol Sci. 2019;20:882. - Equally contributed first author.

45. Yamamoto D, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-Mapper: Simple and complete freeware for fluorescence quantification in zebrafish images. Zebrafish. 2019;16:233-239. - Corresponding author.

44. Okazaki F, Zang L, Nakayama H, Chen Z, Gao Z, Chiba H, Hui S, Aoki T, Nishimura N, Shimada Y*. Microbiome alteration in Type 2 Diabetes Mellitus model of zebrafish. Sci Rep. 2019;9:867. - Equally contributed first and corresponding author.

2018
43. Nakayama H, Shimada Y*, Zang L, Terasawa M, Nishiura K, Matsuda K, Toombs C,  Langdon C, Nishimura N. A novel anti-obesity properties of Palmaria mollis in zebrafish and mouse models. Nutrients. 2018;10:1401. - Equally contributed first and corresponding author.

42. Chen Z, Wu Y, Zang L, Shimada Y, Nakayama H, Rojeet S, Zhao Y, Miura Y, Nishimura N, Chiba H, Hui S. Lipidomic profiling on oxidized phospholipids in Type 2 Diabetes Mellitus model zebrafish. Anal Sci. 2018;34:1201-1208.

41. Yang J, Meng Z, Liu Q, Shimada Y, Olsthoorn RC, Spaink HP, Herrmann A, Kros A. Performing DNA nanotechnology operations on a zebrafish. Chem Sci. 2018;9:7271-7276.

40. Nakayama H, Katayama K, Onabe Y, Sato A, Nishimura N, Shimada YDried Rotifer Sheet: A Novel Live Feed for Rearing First-Feeding Larvae. Zebrafish. 2018;15:291-294. Equally contributed first and corresponding author.

2017
39. Zang L, Shimada Y, Nishimura N. Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Sci Rep. 2017;7:1461. - Equally contributed first author.

38. Ashikawa Y, Nishimura Y, Okabe S, Sato Y, Yuge M, Tada T, Miyao H, Murakami S, Kawaguchi K, Sasagawa S, Shimada Y, Tanaka T. Protective function of the sterol regulatory element binding factor 1–fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 2017;3:3.

2016
37. Yang J, Shimada Y*, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A. Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. ACS Nano. 2016;10:7428-7435. - Equally contributed first and corresponding author.

36. Inoue A, Nishimura Y, Matsumoto N, Umemoto N, Shimada Y, Maruyama T, Kayasuga K, Morihara M, Katagi J, Shiroya T, Hirota Y, Kim S, Tanaka T. Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs. Fundam. Toxicol. Sci. 2016;3:79-87.

35. Zhang B, Shimada Y*, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98 - Equally contributed first author.

2015
34. Nishimura Y, Sasagwa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Front Pharmacol. 2015;6:19

33. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. Repeated Blood Collection for Blood Tests in Adult Zebrafish. J Vis Exp. 2015;102:e53272.


31. Shimada Y, Kuninaga S, Ariyoshi M, Zhang B, Shiina Y, Takahashi Y, Umemoto N, Nishimura Y, Enari H and Tanaka T. E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutr Metab. 2015;12:17.

30. Zhang B, Shimada Y*, Kuroyanagi J, Ariyoshi M, Nomoto T, Shintou T, Umemoto N, Nishimura Y, Miyazaki T, Tanaka T. In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 2015;52:14-25. - Equally contributed first author.

29. Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T. Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015;143:374-384.

28. Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S. Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. J Nanosci Nanotechnol. 2015;15:2140-2147.

2014
27. Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T. Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour Biol. 2014;35:11861-11869.

26. Zang L, Shimada Y, Kawajiria J, Tanaka T, Nishimura N. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. J Funct Foods. 2014;10:499-510.

25. Kuroyanagi J, Shimada Y*, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS Lett. 2014;588:3409-3016. - Equally contributed first author.

24. Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T. Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenit Anom (Kyoto). 2015;55:1-16.

23. Shimada Y, Nishimura Y, Tanaka T. Zebrafish-based systems pharmacology of cancer metastasis. Methods Mol Biol. 2014;1165: 223-238.

22. Zhang B, Shimada Y, Kuroyanagi J, Umemoto N, Nishimura Y, Tanaka T. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 2014;9:e85439.

21. Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014;4:3708. - Equally contributed first author.

2013
20. Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. Int J Obes. 2013;38:1053-1060.

19. Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T. Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish. Mol Biotechnol. 2013;55:131-142.

18. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 2013;10:425-432.

17. Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T. Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. ACS Chem Neurosci. 2013;4:1183-1193.

2012
16. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening. PLoS One. 2012;7:e52549.

15. Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci. 2012;13:101.

14. Hasumura T, Shimada Y, Kuroyanagi J, Nishimura Y, Meguro S, Takema Y, Tanaka T. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutr Metab. 2012;9:73.

2011
13. Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N. A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 2011;8:203-220.

12. Tainaka T, Shimada Y*, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T. Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutr Metab. 2011;8:88. - Equally contributed first author.

11. Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N and Tanaka T. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol. 2010;10:21.

10. Watanabe K, Nishimura Y, Oka T, Nomoto T, Kon T, Shintou T, Hirano M, Shimada Y, Umemoto N, Kuroyanagi J, Wang Z, Zhang Z, Nishimura N, Miyazaki T, Imamura T, Tanaka T. In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci. 2010;11:116.

9. Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T and Tanaka T. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur J Pharmacol. 2009;620:16-20.

8. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, Oka T, Sakamoto C, Kuroyanagi J and Tanaka T. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27.

7. Tanaka T, Oka T, Shimada Y, Umemoto N, Kuroyanagi J, Sakamoto C, Zang L, WangZ, Nishimura Y. Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. J Pharmacol Sci. 2008;107:8-14.

6. Ito Y, Hirano M, Umemoto N, Zang L, Wang Z, Oka T, Shimada Y, Nishimura Y, Kurokawa I, Mizutani H, Tanaka T. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. BMB Rep. 2008;41:139-145.

5. Matsumoto T, Komori T, Yamamoto M, Shimada Y, Nakagawa M, Shiroyama T, Inui K, Ok8azaki Y. Prior intraperitoneal injection of rat recombinant IL-6 increases hypothalamic IL-6 contents in subsequent forced swim stressor in rats. Neuropsychobiology. 2006;54:186-194.

4. Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Biochem Biophys Res Commun. 2006;351:185-191.

3. Ogasawara M, Satoh N, Shimada Y, Wang Z, Tanaka T, Noji S. Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses. Dev Genes Evol. 2006;216:100-104.

2. Masunaga R, Nagasaka A, Sawai Y, Hayakawa N, Nakai A, Hotta K, Kato Y, Hishida H, Takahashi H, Naka M, Shimada Y, Tanaka T, Hidaka H, Itoh M. Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters. J Mol Cell Cardiol. 2004;37:767-774.

1. Hayashi M, Shimada Y, Nishimura Y, Hama T, Tanaka T. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem Biophys Res Commun. 2002;297:1253-1258


Publication List (Japanese) 
1. 島田康人
悪性腫瘍モデルゼブラフィッシュを利用した創薬研究
生体の科学2018、69巻、4号、p365-370

2. 臧黎清、島田康人、西村訓弘
食餌性肥満ゼブラフィッシュを用いた天然由来抗肥満成分の探索研究
日本未病システム学会雑誌2016、22巻、2号、p62-66

3. 田中利男、西村有平、島田康人
オミックス創薬科学とターゲットバリデーション
臨床薬理 2011 42巻、p169-170 

4. 黒柳淳哉、島田康人、西村有平、田中利男
新しいヒト癌移植モデルにおける腫瘍血管新生の薬理ゲノミクス研究 
血管 2011、34巻、3号、p123-128 

5. 田中利男,西村有平、島田康人 
新しい生活習慣病モデル動物と薬理ゲノミクス機構 
比較内分泌学 2010、36巻、136号、p38-43 

6. 田中利男、西村有平、島田康人 
薬理ゲノミクスネットワーク解析による次世代創薬科学 
遺伝子医学MOOK 2009、14号、次世代創薬テクノロジ 実践:インシリコ創薬の最前線、第3章 

7. 田中利男、西村有平、島田康人、岡 岳彦 
運動と生活習慣病の新しい薬理ゲノミクスネットワーク解析 
臨床スポーツ医学 2008、25巻、10号、p1125-1131 

8. 田中利男、岡岳彦、平野稔、臧黎清、伊藤芳幸、島田康人 
血管リモデリングのゲノム創薬科学 
日本臨床 2006、64巻、5号、p576~582
 

9. 田中利男、島田康人、伊藤芳幸 
血管障害の薬理ゲノミクス/インフォマティクス 
THERAPEUTIC RESEARCH 2006、27巻、1号、p51~57 

10. 島田康人、西村有平、田中利男 
第5章カルシウムシグナリングと細胞機能 
生物薬科学実験講座7情報伝達物質Ⅱ 2005、廣川書店、p445~463 

11. 島田康人、田中利男  
抗精神病薬の薬理ゲノミクス  
CLINICAL NEUROSCIENCE 2002、20巻、p738-739

Patent List (Japan) 
  1. 特開2016-204361 グアイアズレン誘導体、がん細胞阻害薬及び前立腺がん細胞阻害薬
  2. 特開2016-021947 イメージング用小魚管理装置及びそれに用いられる小魚用イメージングプレート 
  3. 特開2015-151366 養殖魚類、畜産動物、ペット動物の内臓脂肪蓄積を抑制する素材、及び該素材を用いた動物用飼料
  4. 特開2014-169951 小魚類イメージング装置用の小魚類配列装置
  5. 特開2014-101359 がん細胞阻害薬、がん幹細胞検出用プローブ
  6. 特開2014-101358 がん細胞阻害薬、がん幹細胞検出用プローブ
  7. 特開2014-100139 異種細胞移植モデル動物の作製方法
  8. 特開2014-083008 透明ゼブラフィッシュの作製方法、及び当該方法によって作製されたゼブラフィッシュを用いた生体イメージング評価法
  9. 特開2012-184217 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法
  10. 特開2012-125194 腫瘍血管新生制御遺伝子
  11. 特開2011-217651 小型水生動物実験飼育水槽システム
  12. 特開2011-148794 中枢神経系組織標識用組成物、中枢神経系組織の標識方法、及び中枢神経系組織標識用組成物を用いたスクリーニング方法(PMT出願)
  13. 特開2011-148793 経鼻中枢神経系組織標識用組成物、経鼻中枢神経系組織標識用組成物を用いた標識方法及びスクリーニング方法
  14. 特開2011-055755 MXD3遺伝子の発現阻害による肥満の抑制
  15. 特開2010-276559 試料観察システム及び試料観察方法
  16. 特開2010-273655 細胞保持方法、細胞試験方法及び細胞処理装置
  17. 特開2010-273654 物体保持用シート、試験方法及び物体処理装置
  18. 特開2010-169678 生物試料用標識剤並びに該標識剤を用いた標識方法及びスクリーニング方法
  19. 特開2010-169677 有毛細胞標識剤、及び該標識剤を用いた有毛細胞標識方法
  20. 特開2010-168369 眼内組織用標識組成物、眼内組織の標識方法及びスクリーニング方法
  21. 特開2010-148447 網膜組織染色組成物、網膜組織の染色方法
  22. 国際特許公開特開2009-148249 生体の保存方法、生体の試験方法、生体の生育方法、生体の 保持用シートおよび生体の処理装置
  23. 特開2009-038977 小型魚類機能評価システム
  24. 特開2008-193912 心不全治療薬のスクリーニング方法
  25. 特開2008-118882 トルサード・ド・ポアンツ型心室頻拍を呈するゼブラフィッシュ
  26. 特開2007-129982 心不全症状を呈するゼブラフィッシュ

Patent List (World) 
1. US. 2015/0139908, May. 21, 2015. Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method
2. US. 2014/0112869, Jan. 2, 2014. Central nervous system labelling composition for intranasal administration and labelling method and screening method using central nervous system labelling composition for intranasal administration
3. US. 2013/0280169, Jun. 19, 2013. Central nervous system tissue-labeling composition, method for labeling central nervous system tissue, and screening method using central nervous system tissue-labeling composition
4. US 2012/0207683 A1, Aug. 16, 2012. Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability
5. US. 2010/0304428, May. 26, 2010. Cell holding method, cell testing method and cell handling apparatus
6. US. 2010/0300547, May. 26, 2010. Object-holding sheet, test method and object-treating equipment
7. US. 2010/0302534, May. 26, 2010. Sample observation system and sample observation process
8. US 2009/8460639, Dec. 22, 2009. Probe for a hair cell, and labelling method for a hair cell using the probe for a hair cell.
9. US. 2010/0221831, Nov. 27, 2008. Living body holding method, living body test method, living body growing method, living body holding sheet, and living body processing device

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