Publication List (English)

54. Shimada Y*, Hazekawa MDeveloping a model for a siRNA delivery system by cancer implantation into zebrafish circulationMethods Mol Biol. 2019;in press. - First and corresponding author.

53. Yamada Y, Chensom S, Yonemoto H, Nakayama H, Zang L, Nishimura N, Mishima T, Shimada Y*. Water extract of Yamato-Tachibana (Citrus tachibana) induces food intake in adult and larval zebrafish. J Med Food. 2019; [Epub ahead of print]. - Corresponding author.

52. Sawaki R, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-AutoML: An easy machine learning-based method to detect anomalies in fluorescent-labelled zebrafishInventions. 2019;4:72. - Corresponding author.

50. Zang L, Shimada Y, Nakayama H, Kim Y, Chu D, Juneja LR, Kuroyanagi J, Nishimura N. RNA-seq based transcriptome analysis of the anti-obesity effect of green tea extract using zebrafish obesity models. Molecules. 2019;24:3256.

49. Monma Y, Shimada Y, Nakayama H, Zang L, Nishimura N, Tanaka T. Aging-associated microstructural deterioration of vertebra in zebrafishBone Rep. 2019;11:100215.- Equally contributed first author.

48. Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N. Therapeutic silencing of centromere protein X ameliorates hyperglycemia in zebrafish and mouse models of type 2 diabetes mellitus. Front Genet. 2019;10:693.

47. Kawada T, Kuroyanagi J, Okazaki F, Taniguchi T, Suda N, Abiko S, Kaneco S, Nishimura N, Shimada Y*. An integrative evaluation method for the biological safety of down and feather materials. Int J Mol Sci. 2019;20:1434. - Corresponding author.

46. Vranic S, Shimada Y*, Ichihara S*, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G. Toxicological evaluation of SiO2 nanoparticles by zebrafish embryo toxicity test. Int J Mol Sci. 2019;20:882. - Equally contributed first author.

45. Yamamoto D, Sato D, Nakayama H, Nakagawa Y, Shimada Y*. ZF-Mapper: Simple and complete freeware for fluorescence quantification in zebrafish images. Zebrafish. 2019;16:233-239. - Corresponding author.

44. Okazaki F, Zang L, Nakayama H, Chen Z, Gao Z, Chiba H, Hui S, Aoki T, Nishimura N, Shimada Y*. Microbiome alteration in Type 2 Diabetes Mellitus model of zebrafish. Sci Rep. 2019;9:867. - Equally contributed first and corresponding author.

43. Nakayama H, Shimada Y*, Zang L, Terasawa M, Nishiura K, Matsuda K, Toombs C,  Langdon C, Nishimura N. A novel anti-obesity properties of Palmaria mollis in zebrafish and mouse models. Nutrients. 2018;10:1401. - Equally contributed first and corresponding author.

42. Chen Z, Wu Y, Zang L, Shimada Y, Nakayama H, Rojeet S, Zhao Y, Miura Y, Nishimura N, Chiba H, Hui S. Lipidomic profiling on oxidized phospholipids in Type 2 Diabetes Mellitus model zebrafish. Anal Sci. 2018;34:1201-1208.

41. Yang J, Meng Z, Liu Q, Shimada Y, Olsthoorn RC, Spaink HP, Herrmann A, Kros A. Performing DNA nanotechnology operations on a zebrafish. Chem Sci. 2018;9:7271-7276.

40. Nakayama H, Katayama K, Onabe Y, Sato A, Nishimura N, Shimada YDried Rotifer Sheet: A Novel Live Feed for Rearing First-Feeding Larvae. Zebrafish. 2018;15:291-294. Equally contributed first and corresponding author.

39. Zang L, Shimada Y, Nishimura N. Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Sci Rep. 2017;7:1461. - Equally contributed first author.

38. Ashikawa Y, Nishimura Y, Okabe S, Sato Y, Yuge M, Tada T, Miyao H, Murakami S, Kawaguchi K, Sasagawa S, Shimada Y, Tanaka T. Protective function of the sterol regulatory element binding factor 1–fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 2017;3:3.

37. Yang J, Shimada Y*, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A. Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. ACS Nano. 2016;10:7428-7435. - Equally contributed first and corresponding author.

36. Inoue A, Nishimura Y, Matsumoto N, Umemoto N, Shimada Y, Maruyama T, Kayasuga K, Morihara M, Katagi J, Shiroya T, Hirota Y, Kim S, Tanaka T. Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs. Fundam. Toxicol. Sci. 2016;3:79-87.

35. Zhang B, Shimada Y*, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98 - Equally contributed first author.

34. Nishimura Y, Sasagwa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Front Pharmacol. 2015;6:19

33. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. Repeated Blood Collection for Blood Tests in Adult Zebrafish. J Vis Exp. 2015;102:e53272.

31. Shimada Y, Kuninaga S, Ariyoshi M, Zhang B, Shiina Y, Takahashi Y, Umemoto N, Nishimura Y, Enari H and Tanaka T. E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutr Metab. 2015;12:17.

30. Zhang B, Shimada Y*, Kuroyanagi J, Ariyoshi M, Nomoto T, Shintou T, Umemoto N, Nishimura Y, Miyazaki T, Tanaka T. In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 2015;52:14-25. - Equally contributed first author.

29. Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T. Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015;143:374-384.

28. Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S. Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. J Nanosci Nanotechnol. 2015;15:2140-2147.

27. Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T. Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour Biol. 2014;35:11861-11869.

26. Zang L, Shimada Y, Kawajiria J, Tanaka T, Nishimura N. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. J Funct Foods. 2014;10:499-510.

25. Kuroyanagi J, Shimada Y*, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS Lett. 2014;588:3409-3016. - Equally contributed first author.

24. Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T. Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenit Anom (Kyoto). 2015;55:1-16.

23. Shimada Y, Nishimura Y, Tanaka T. Zebrafish-based systems pharmacology of cancer metastasis. Methods Mol Biol. 2014;1165: 223-238.

22. Zhang B, Shimada Y, Kuroyanagi J, Umemoto N, Nishimura Y, Tanaka T. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 2014;9:e85439.

21. Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014;4:3708. - Equally contributed first author.

20. Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. Int J Obes. 2013;38:1053-1060.

19. Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T. Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish. Mol Biotechnol. 2013;55:131-142.

18. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 2013;10:425-432.

17. Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T. Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. ACS Chem Neurosci. 2013;4:1183-1193.

16. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening. PLoS One. 2012;7:e52549.

15. Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci. 2012;13:101.

14. Hasumura T, Shimada Y, Kuroyanagi J, Nishimura Y, Meguro S, Takema Y, Tanaka T. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutr Metab. 2012;9:73.

13. Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N. A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 2011;8:203-220.

12. Tainaka T, Shimada Y*, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T. Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutr Metab. 2011;8:88. - Equally contributed first author.

11. Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N and Tanaka T. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol. 2010;10:21.

10. Watanabe K, Nishimura Y, Oka T, Nomoto T, Kon T, Shintou T, Hirano M, Shimada Y, Umemoto N, Kuroyanagi J, Wang Z, Zhang Z, Nishimura N, Miyazaki T, Imamura T, Tanaka T. In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci. 2010;11:116.

9. Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T and Tanaka T. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur J Pharmacol. 2009;620:16-20.

8. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, Oka T, Sakamoto C, Kuroyanagi J and Tanaka T. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27.

7. Tanaka T, Oka T, Shimada Y, Umemoto N, Kuroyanagi J, Sakamoto C, Zang L, WangZ, Nishimura Y. Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. J Pharmacol Sci. 2008;107:8-14.

6. Ito Y, Hirano M, Umemoto N, Zang L, Wang Z, Oka T, Shimada Y, Nishimura Y, Kurokawa I, Mizutani H, Tanaka T. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. BMB Rep. 2008;41:139-145.

5. Matsumoto T, Komori T, Yamamoto M, Shimada Y, Nakagawa M, Shiroyama T, Inui K, Ok8azaki Y. Prior intraperitoneal injection of rat recombinant IL-6 increases hypothalamic IL-6 contents in subsequent forced swim stressor in rats. Neuropsychobiology. 2006;54:186-194.

4. Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Biochem Biophys Res Commun. 2006;351:185-191.

3. Ogasawara M, Satoh N, Shimada Y, Wang Z, Tanaka T, Noji S. Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses. Dev Genes Evol. 2006;216:100-104.

2. Masunaga R, Nagasaka A, Sawai Y, Hayakawa N, Nakai A, Hotta K, Kato Y, Hishida H, Takahashi H, Naka M, Shimada Y, Tanaka T, Hidaka H, Itoh M. Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters. J Mol Cell Cardiol. 2004;37:767-774.

1. Hayashi M, Shimada Y, Nishimura Y, Hama T, Tanaka T. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem Biophys Res Commun. 2002;297:1253-1258

Publication List (Japanese) 
1. 島田康人

2. 臧黎清、島田康人、西村訓弘

3. 田中利男、西村有平、島田康人
臨床薬理 2011 42巻、p169-170 

4. 黒柳淳哉、島田康人、西村有平、田中利男
血管 2011、34巻、3号、p123-128 

5. 田中利男,西村有平、島田康人 
比較内分泌学 2010、36巻、136号、p38-43 

6. 田中利男、西村有平、島田康人 
遺伝子医学MOOK 2009、14号、次世代創薬テクノロジ 実践:インシリコ創薬の最前線、第3章 

7. 田中利男、西村有平、島田康人、岡 岳彦 
臨床スポーツ医学 2008、25巻、10号、p1125-1131 

8. 田中利男、岡岳彦、平野稔、臧黎清、伊藤芳幸、島田康人 
日本臨床 2006、64巻、5号、p576~582

9. 田中利男、島田康人、伊藤芳幸 
THERAPEUTIC RESEARCH 2006、27巻、1号、p51~57 

10. 島田康人、西村有平、田中利男 
生物薬科学実験講座7情報伝達物質Ⅱ 2005、廣川書店、p445~463 

11. 島田康人、田中利男  





1/13: 未病学会 (11/17記事)
1/13: デンソー (11/6記事)
1/13: 信楽 (11/4記事)
1/12: 中国3 (9/22記事)
1/12: 中国2 (9/20記事)
1/12: 中国1 (9/19記事)
12/27: Published (12/17記事)
12/27: ZMDD2019 (11/2記事)
12/27: 京都大学 (10/7記事)
12/27: 彦根・安土城 (9/15記事)
12/22: Published (12/17記事)
12/22: Published (11/20記事)
12/22: Doctors File (11/9記事)
12/22: 鳥取 (9/11記事)
12/22: 羽毛研究 (9/9記事)
12/22: スペイン4 (8/21記事)
12/22: クラウドファンド (8/22記事)
12/22: スペイン3 (8/20記事)
12/22: スペイン2 (8/18記事)
12/22: スペイン1 (8/17記事)


12 | 2020/01 | 02
- - - 1 2 3 4
5 6 7 8 9 10 11
12 13 14 15 16 17 18
19 20 21 22 23 24 25
26 27 28 29 30 31 -