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Publication List (English)
1. Nakayama H, Katayama K, Onabe Y, Sato A, Nishimura N, Shimada YDried Rotifer Sheet: A Novel Live Feed for Rearing First-Feeding Larvae. Zebrafish. 2018. [Epub ahead of print]. *equally contributed first and corresponding author.

2. Zang L, Shimada Y, Nishimura N. Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. Sci Rep. 2017;7:1461. *equally contributed first author.

3. Ashikawa Y, Nishimura Y, Okabe S, Sato Y, Yuge M, Tada T, Miyao H, Murakami S, Kawaguchi K, Sasagawa S, Shimada Y, Tanaka T. Protective function of the sterol regulatory element binding factor 1–fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 2017;3:3.

4. Yang J, Shimada Y*, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A. Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. ACS Nano. 2016;10:7428-7435. *equally contributed first and corresponding author

5. Inoue A, Nishimura Y, Matsumoto N, Umemoto N, Shimada Y, Maruyama T, Kayasuga K, Morihara M, Katagi J, Shiroya T, Hirota Y, Kim S, Tanaka T. Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs. Fundam. Toxicol. Sci. 2016;3:79-87.

6. Zhang B, Shimada Y*, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Transl Res. 2016;170:89-98 *equally contributed first author

7. Nishimura Y, Sasagwa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Front Pharmacol. 2015;6:19

8. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. Repeated Blood Collection for Blood Tests in Adult Zebrafish. J. Vis. Exp. 2015;102:e53272.


10. Shimada Y, Kuninaga S, Ariyoshi M, Zhang B, Shiina Y, Takahashi Y, Umemoto N, Nishimura Y, Enari H and Tanaka T. E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutr Metab. 2015;12:17.

11. Zhang B, Shimada Y*, Kuroyanagi J, Ariyoshi M, Nomoto T, Shintou T, Umemoto N, Nishimura Y, Miyazaki T, Tanaka T. In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 2015;52:14-25 *equally contributed first author

12. Kawabata M, Umemoto N, Shimada Y, Nishimura Y, Zhang B, Kuroyanagi J, Miyabe M, Tanaka T. Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicol Sci. 2015;143:374-384.

13. Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S. Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. J Nanosci Nanotechnol. 2015;15:2140-2147.

14. Zhang B, Shimada Y, Kuroyanagi J, Nishimura Y, Umemoto N, Nomoto T, Shintou T, Miyazaki T, Tanaka T. Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour Biol. 2014;35:11861-11869.

15. Zang L, Shimada Y, Kawajiria J, Tanaka T, Nishimura N. Effects of Yuzu (Citrus junos Siebold ex Tanaka) peel on the diet-induced obesity in a zebrafish model. J Funct Foods. 2014;10:499-510.

16. Kuroyanagi J, Shimada Y*, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS Lett. 2014;588:3409-3016. *equally contributed first author

17. Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T. Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenit Anom (Kyoto). 2015;55:1-16.

18. Shimada Y, Nishimura Y, Tanaka T. Zebrafish-based systems pharmacology of cancer metastasis. Methods Mol Biol. 2014;1165: 223-238.

19. Zhang B, Shimada Y, Kuroyanagi J, Umemoto N, Nishimura Y, Tanaka T. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 2014;9:e85439.

20. Hiramitsu M, Shimada Y, Kuroyanagi J, Inoue T, Katagiri T, Zang L, Nishimura Y, Nishimura N, Tanaka T. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Sci Rep. 2014;4:3708 *equally contributed first author

21. Shimada Y, Kuroyanagi J, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T. Downregulation of max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. Int J Obes. 2013;38:1053-1060.

22. Umemoto N, Nishimura Y, Shimada Y, Yamanaka Y, Kishi S, Ito S, Okamori K, Nakamura Y, Kuroyanagi J, Zhang Z, Zang L, Wang Z, Nishimura N, Tanaka T. Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish. Mol Biotechnol. 2013;55:131-142.

23. Zang L, Shimada Y, Nishimura Y, Tanaka T, Nishimura N. A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 2013;10:425-432.

24. Nishimura Y, Yata K, Nomoto T, Ogiwara T, Watanabe K, Shintou T, Tsuboyama A, Okano M, Umemoto N, Zhang Z, Kawabata M, Zhang B, Kuroyanagi J, Shimada Y, Miyazaki T, Imamura T, Tomimoto H, Tanaka T. Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. ACS Chem Neurosci. 2013;4:1183-1193.

25. Shimada Y, Hirano M, Nishimura Y, Tanaka T. A High-Throughput Fluorescence-Based Assay System for Appetite-Regulating Gene and Drug Screening. PLoS One. 2012;7:e52549.

26. Watanabe K, Nishimura Y, Nomoto T, Umemoto N, Zhang Z, Zhang B, Kuroyanagi J, Shimada Y, Shintou T, Okano M, Miyazaki T, Imamura T, Tanaka T. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci. 2012;13:101.

27. Hasumura T, Shimada Y, Kuroyanagi J, Nishimura Y, Meguro S, Takema Y, Tanaka T. Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutr Metab. 2012;9:73.

28. Zang L, Morikane D, Shimada Y, Tanaka T, Nishimura N. A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 2011;8:203-220.

29. Tainaka T, Shimada Y*, Kuroyanagi J, Zang L, Oka T, Nishimura Y, Nishimura N, Tanaka T. Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutr Metab. 2011;8:88 *equally contributed first author

30. Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N and Tanaka T. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol. 2010;10:21.

31. Watanabe K, Nishimura Y, Oka T, Nomoto T, Kon T, Shintou T, Hirano M, Shimada Y, Umemoto N, Kuroyanagi J, Wang Z, Zhang Z, Nishimura N, Miyazaki T, Imamura T, Tanaka T. In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci. 2010;11:116.

32. Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T and Tanaka T. Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm. Eur J Pharmacol. 2009;620:16-20.

33. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, Oka T, Sakamoto C, Kuroyanagi J and Tanaka T. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27.

34. Tanaka T, Oka T, Shimada Y, Umemoto N, Kuroyanagi J, Sakamoto C, Zang L, WangZ, Nishimura Y. Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. J Pharmacol Sci. 2008;107:8-14.

35. Ito Y, Hirano M, Umemoto N, Zang L, Wang Z, Oka T, Shimada Y, Nishimura Y, Kurokawa I, Mizutani H, Tanaka T. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. BMB Rep. 2008;41:139-145.

36. Matsumoto T, Komori T, Yamamoto M, Shimada Y, Nakagawa M, Shiroyama T, Inui K, Okazaki Y. Prior intraperitoneal injection of rat recombinant IL-6 increases hypothalamic IL-6 contents in subsequent forced swim stressor in rats. Neuropsychobiology. 2006;54:186-194.

37. Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Biochem Biophys Res Commun. 2006;351:185-191.

38. Ogasawara M, Satoh N, Shimada Y, Wang Z, Tanaka T, Noji S. Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses. Dev Genes Evol. 2006;216:100-104.

39. Masunaga R, Nagasaka A, Sawai Y, Hayakawa N, Nakai A, Hotta K, Kato Y, Hishida H, Takahashi H, Naka M, Shimada Y, Tanaka T, Hidaka H, Itoh M. Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters. J Mol Cell Cardiol. 2004;37:767-774.

40. Hayashi M, Shimada Y, Nishimura Y, Hama T, Tanaka T. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem Biophys Res Commun. 2002;297:1253-1258


Publication List (Japanese) 
1. 臧黎清、島田康人、西村訓弘
食餌性肥満ゼブラフィッシュを用いた天然由来抗肥満成分の探索研究
日本未病システム学会雑誌2016、22巻、2号、p62-66

2. 田中利男、西村有平、島田康人
オミックス創薬科学とターゲットバリデーション
臨床薬理 2011 42巻、p169-170 

3. 黒柳淳哉、島田康人、西村有平、田中利男
新しいヒト癌移植モデルにおける腫瘍血管新生の薬理ゲノミクス研究 
血管 2011、34巻、3号、p123-128 

4. 田中利男,西村有平、島田康人 
新しい生活習慣病モデル動物と薬理ゲノミクス機構 
比較内分泌学 2010、36巻、136号、p38-43 

5. 田中利男、西村有平、島田康人 
薬理ゲノミクスネットワーク解析による次世代創薬科学 
遺伝子医学MOOK 2009、14号、次世代創薬テクノロジ 実践:インシリコ創薬の最前線、第3章 

6. 田中利男、西村有平、島田康人、岡 岳彦 
運動と生活習慣病の新しい薬理ゲノミクスネットワーク解析 
臨床スポーツ医学 2008、25巻、10号、p1125-1131 

7. 田中利男、岡岳彦、平野稔、臧黎清、伊藤芳幸、島田康人 
血管リモデリングのゲノム創薬科学 
日本臨床 2006、64巻、5号、p576~582
 

8. 田中利男、島田康人、伊藤芳幸 
血管障害の薬理ゲノミクス/インフォマティクス 
THERAPEUTIC RESEARCH 2006、27巻、1号、p51~57 

9. 島田康人、西村有平、田中利男 
第5章カルシウムシグナリングと細胞機能 
生物薬科学実験講座7情報伝達物質Ⅱ 2005、廣川書店、p445~463 

10. 島田康人、田中利男  
抗精神病薬の薬理ゲノミクス  
CLINICAL NEUROSCIENCE 2002、20巻、p738-739

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